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Aspirin
Proven Again to Prevent Atherosclerosis--Vitamin E Questionable
Lancet, the British medical journal* has just published a report on
4,495 patients showing a
relative risk for atherosclerosis 'hardening of the
arteries] of those given aspirin to be 56% of the risk for those not
taking it. Researchers
used a 100mg. pill, equivalent to about one-third of a conventional
tablet.
Also tested were patients taking a 300 mg dose of vitamin E a day,
though no conclusive benefit was seen for this group. Since previous
studies have found a clear benefit for aspirin as well as for vitamin E,
how come the vitamin failed in this test? The authors called this
outcome a "false negative." They observed that the test was
ended prematurely, since the obvious health benefit of the aspirin
required, ethically, giving aspirin to those patients who had been
given
a placebo (plain sugar pill.)
Thus all the subjects
ended up getting aspirin.
Was the early ending of the trial the real reason for vitamin E's poor
showing? In our view, the physicians missed something. If this study is
reported on by the major media, we suspect they might miss it too.
Buried in the report was a reference to the vitamin E.
It said that synthetic E was used. Since natural E has some
twice
the effectiveness of synthetic, this could be the explanation for
its failure.
The success of the low-dose aspirin was found in the reduction of
cardiovascular deaths, nonfatal heart attacks and nonfatal strokes. For
all strokes, those taking the drug had a risk of only two-thirds of
those not taking it.
Side effects? Certainly aspirin increases the risk of bleeding in the
stomach. Yet only one of the entire group's bleeding was fatal.
And,..."among the roughly 8000 person-years of aspirin treatment
there was no suggestion of an excess risk for 'hemorrhage.]"
This report therefore unwittingly also casts some doubt over the use by
physicians of exorbitantly priced aspirin substitutes intended to reduce
the internal bleeding caused by aspirin.
*The study appeared in Lancet, vol. 357, 2001, and was done by the
Collaborative Group of the Primary Prevention Project in Italy.
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