"Results: Acetaminophen*at a dose of 1 gram per kilogram of body weight produced 100% mortality in 'animals tested.]"--Medical Science Monitor, vol. 11, 2005.

"p-Aminophenol, a metabolite 'product produced by the body from the drug] is nephrotoxic 'toxic to the liver.]"--Toxicol. App. Pharmacol., vol. 209, 2005.

"CONCLUSIONS: Each year a substantial numbers of Americans experience intentional and unintentional acetaminophen*-associated overdoses that, in severe cases, lead to serious illness and possible death."--Pharmacolepid. Drug Safety, Nov. 18, 2005.

"Severe acetaminophen* heptotoxicity 'liver toxicity] frequently leads to acute liver failure (ALF)...'In studying the records at 22 health care centers] ..In conclusion, acetaminophen 'liver poisoning] far exceeds other causes of liver failure in the U.S."--Hepatology, vol. 42, 2005.

The Asia Pac. J. of Clinical Nutrition, vol. 14, 2005 further reported that paracetamol* reduces the body's availability of calcium.

A National Inst. of Health (U.S. govt.)-originated report in the J. of Pharmacol. & Exp. Therapuetics reported, "...our results show that 'acetaminophen] or its metabolites can directly reduce the p53 content of glioma 'brain cells]..." It should be noted that the p53 gene in our bodies is a prime defense against cancer. Report above dated Dec. 5, 2005.

We could go on; J. Pheumatol., BMC Cancer, Southern Med. J., Epidemiology, ad infinitem, but the above are quite representative.

*In each instance, the word acetaminophen would apply likewise to Tylenol (t.m.) and to paracetamol.