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Crohn's,
IBD and Colitis--Any Nutrients Found Helpful?
"Inflammatory bowel disease is a disorder characterized by ...inflammation
of the
gastrointestinal tract. There are two basic disorders, ulcerative colitis (UC)
and Crohn's Disease. UC affects mainly the colon, where inflammatory changes
are limited to the mucusa 'mucus membrane tissue lining]. Medical therapy
using pharmacological agents can induce remission; however, in the
long-term it may result in adverse side effects.
"Dietary management of UC proves effective therapy without the adverse
effects of either surgery or medications',] and exclusive enteric
nutrition 'direct feeding to the intestines] using formulated food is
efficacious primary therapy for active IBD, although the mode of action is
poorly understood.
"Although few clinical studies suggest a dramatic influence of diet or
nutritional supplementation in UC because like many chronic disease, it 'has
several factors], some evidence indicates that a high intake of (n-3)
'poly unsaturated fats] such as (EPA)* may have anti-inflammatory effects in
patients with UC...
"'CONCLUSION OF OUR STUDIES:] Taken together, these data suggest that
dietary
intake of (n-3) 'fish oils], even in low-fat diets, ameliorate the
intestinal damage of UC...; FO 'fish oil] supplementation
down-regulates pro-inflammatory 'factors], such as tumor necrosis factor,
interleukin-1 and inteleukin-6, which may in turn lessen...oxidative
damage." 'Emphases are added.]
From The Journal of Nutrition, vol. 132, 2002. By Nieto, Toprres, Rios and
Gill, Depts. Of Biochemistry and Molecular Biology and Cell Biology, U. of
Grenada, 18071, Spain.
*Eicosapentaenoic
acid, one of the two fish oil ingredients.
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